Semi-Pro

Will Ferrell

Megamind (voice)

Collette Wolfe

Melinda

Woody Harrelson

Moe Berkus

Jackie Earle Haley

Richard Sayre

Paul Rust

Wheelchair Darren

Will Arnett

Brent Wilts

Kristen Wiig

Bear Handler

David Koechner

Co-Pilot

Kate Luyben

Staci Moon (uncredited)

Steve Bannos

Math Teacher

Ian Roberts

Kyle

Ed Helms

Peter Reynolds

Brian Huskey

Elementary Principal

Tim Meadows

Mr. Duvall

Scot Armstrong

Cameraman

Danny Mooney

Party Griller (uncredited)

Rob Corddry

Kyle

Maura Tierney

Abby Lockhart

Jason Sudeikis

Nacho Fan

André 3000

Clarence

Matt Walsh

Self - Correspondent

Andy Daly

Dick Pepperfield

DeRay Davis

Bee Bee Ellis

Andy Richter

Gregory

Gary Teague

Baseball Fan

Ellia English

Ms. Quincy

Pat Kilbane

Petrelli

Noel Conlon

Man Being Hugged

Jerry Minor

Paul the DJ (uncredited)

Charlyne Yi

Wheelchair Jody

Patti LaBelle

Jackie's Mom

Gil Glasgow

Losing Owner #2

Phil Hendrie

Nets Coach

Margaret Newborn

Jazz Club Goer (uncredited)

Steve Seagren

Losing Owner #1

Josh Braaten

Twiggy Munson

Jay Phillips

Scootsie Double Day

Justen Naughton

Squires Player #31 (uncredited)

Grayson Boucher

Spirits Player #31 / Spurs Player #22 (uncredited)

James Markham Hall Jr.

Associate (uncredited)

David E. Brown

Avid Tropics Fan (uncredited)

Theo Caesar

Tropics Fan (uncredited)

Warren Sweeney

Winning Team Owner #1 (uncredited)

Dante Henderson

Dancer

Shawntay Dalon

Crowd Member (uncredited)

Quinn Hawking

Basketball player (uncredited)

Scotty Atkins

Fan (uncredited)

Anthony Burrell

Dancer

Bruno Sandoval

Spurs Player #41 (uncredited)

Dan Domenech

Ron

Ryan C. Burney

Assist. Scoreboard Operator (uncredited)

Tiffany Michelle

Sarah (uncredited)

Ralph Kampshoff

Detective (segment: Drip)

Briana Barran

Ball Girl

Lili Asvar

Fan (uncredited)

MaShae Alderman

Ball Girl

Kamal Moummad

Starting Point Guard (uncredited)